I wish I had some suggestions.
Trying in a fresh prefix, the launcher fails to run with:
Running /home/maciek/.local/share/lutris/runners/wine/tkg-protonified-4.6-x86_64/bin/wine /home/maciek/Games/renx/drive_c/Program Files (x86)/Renegade X/Launcher/Renegade X Launcher.exe
The entry point method could not be loaded due to Could not load file or assembly 'PresentationFramework, Version=4.0.0.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35' or one of its dependencies.
Waiting on children
All children gone
Exit with returncode 1
Attempting to install .NET 4.5.2 manually from MS gives ".NET Framework 4.5.2 or a later update is already installed on this computer.", and doesn't allow installation.
Winetricks refuses to run now as well
2019-05-15 00:17:17,909: The game doesn't have an executabe
Running /home/maciek/.local/share/lutris/runtime/winetricks/winetricks --unattended
------------------------------------------------------
You are using a 64-bit WINEPREFIX. Note that many verbs only install 32-bit versions of packages. If you encounter problems, please retest in a clean 32-bit WINEPREFIX before reporting a bug.
------------------------------------------------------
Using winetricks 20190310-next - sha256sum: ba32734c7e69ae53929d92184fadcea66836cd5c9ba43694e153b53522d74669 with wine-4.6.r0.g3f8edce5 ( TkG Staging Esync ) and WINEARCH=win64
zenity: symbol lookup error: /usr/lib/libharfbuzz.so.0: undefined symbol: FT_Done_MM_Var
winetricks GUI enabled, using zenity
zenity: symbol lookup error: /usr/lib/libharfbuzz.so.0: undefined symbol: FT_Done_MM_Var
Waiting on children
All children gone
Exit with returncode 0
Oh well, what can one expect from a program written in a Windows-exclusive language >.>